The geopolitical situation in the South Caucasus region has significantly changed following the Second Karabakh War. This commentary analyses the role of Turkey in regional cooperation with the aim of creating a stable and secure environment and further argues that Turkey has become a proactive actor and a game changer for the region. The commentary stresses the fact that Turkey is redefining its status and position in the South Caucasus. The key argument is that Turkey’s role, potential, and contribution can be evaluated within the framework of opportunities and challenges, and explained with reference to the nature of its bilateral relations with the countries of the region.