This article explores the multifaceted geopolitical dynamics underpinning the Middle East and South Caucasus regions and emphasizes the profound historical interconnectedness between them. It highlights the importance of reviving and promoting the interconnectedness and inter-cooperation between the two regions, particularly in an era of changing geopolitical landscapes surrounding the US and Russia. Central to the theme of the article are Iran and Türkiye, two critical regional actors whose roles and policies profoundly influence the interconnectedness of the Middle East and South Caucasus regions. The author argues that, while Iran presents a geographical opportunity to promote interconnectedness, realities on ground reflect another image. In stark contrast, it is argued that Türkiye could be a unifying force. The article sheds light on significant initiatives spearheaded by Türkiye, notably the Middle Corridor, the Gulf Corridor, and the Zangezur Corridor. These endeavors are viewed not just as modern infrastructure projects, but as a reflection of the ancient Silk Road’s spirit of connectivity and cooperation. Against the backdrop of a constantly evolving global geopolitical landscape, the article underscores the paramount importance of bolstering such regional interconnectedness to usher in economic synergies, enhanced security cooperation, and a robust cultural exchange, thereby contributing to regional stability and shared prosperity.